Rejuvenative PDRN-NE Ampoule - Face Serum

THE NEXT LEVEL IN
CELLULAR SKINCARE

NANO-EMULSION
ADVANCED DELIVERY FOR
VISIBLE REJUVENATION

A high-performance rejuvenation program featuring 1% intact salmon-derived PDRN delivered through a proprietary nano-emulsion system to visibly lift, firm, smooth, and revitalize the complexion.

Rejuvenative PDRN-NE Ampoule is a four-week, intensive skin rejuvenation treatment powered by intact Sodium DNA (PDRN) at a clinically optimized 1% concentration. Each set includes four 5ml vials, designed to be used weekly for targeted skin renewal and visible improvements in elasticity, lift, tone, and smoothness.

This advanced serum-emulsion absorbs softly into the skin while providing a comforting veil of moisture—ideal for dry, mature, or fatigued skin that needs visible rejuvenation and support.

PDRN is a naturally occurring DNA polymer known for supporting the skin’s renewal pathways. However, because PDRN is a large molecule, standard serums cannot deliver it effectively.

VENN’s Nano-Emulsion (NE) technology encapsulates intact PDRN in sub-200 nm droplets that protect the molecule, enhance penetration, and release nucleotides gradually to support visible rejuvenation.

The formula is further strengthened with a powerful network of peptides and vegan EGF, 17 amino acids, niosome-encapsulated panthenol, a multi-layer hydration system, and barrier-reinforcing actives including ectoin, ceramide NP, and glutathione. Together, they help improve firmness, elasticity, tone, and radiance while supporting a smoother, healthier-looking complexion.

The treatment’s translucent, faint-blue hue is not from dyes—it is a natural result of the Tyndall effect, confirming true nano-scale dispersion.

Clinical results (based on a 2-week in-vivo clinical study, 20 subjects):
+ Improved surface and deep skin elasticity
+ Visible lifting of cheeks, chin, nasolabial folds, and mouth corners
+ Reduced appearance of wrinkles
+ Reduced visible redness
+ Diminished superficial dark spots and hyperpigmentation
+ Improved look of deep pigmentation

Consumer perception (20 subjects, 2 weeks, morning and evening use):
+ 100% agreed skin felt more elastic, lifted, soothed, healthier, and younger
+ 100% agreed skin tone looked improved and more even; pores looked smaller; skin looked brighter
+ 95% agreed wrinkles around the eyes looked reduced

Cruelty free. Leaping Bunny certified. None of our products, including the ingredients, are tested on animals.

Directions: Use each of the four 5ml vials over the course of one week for a 4-week intensive skin rejuvenation program. Apply 6–9 drops per use, gently squeezing the applicator to dispense the serum into your palm. Using your fingertips, pat the serum evenly across freshly cleansed skin, morning and night. Follow with your preferred VENN moisturizer to complete your routine.

This program may be repeated every 2–3 months or used as a daily serum for ongoing rejuvenation.

Caution: For topical, external use only. Do not use on damaged or irritated skin. Do not use if you are allergic to any of the ingredients. Discontinue use if irritation or rash occurs and consult a physician. Avoid direct contact with eyes. Store in a cool, dry place away from heat and direct sunlight. Keep out of reach of children.

WHAT IS PDRN?

PDRN (Polydeoxyribonucleotide) is a naturally occurring DNA polymer composed of long-chain nucleotide fragments that support the skin’s visible renewal processes. In skincare, PDRN is valued for its ability to help improve the look of elasticity, firmness, and overall skin vitality. However, because PDRN is a large molecule, most topical formulas struggle to deliver it effectively. In our Rejuvenative PDRN-NE Ampoule, we use intact, high-purity PDRN sourced from salmon sperm DNA, paired with our Nano-Emulsion (NE) technology to help enhance penetration and preserve its integrity. This allows PDRN to work more efficiently on the skin’s surface—helping create a smoother, firmer, healthier-looking complexion.

OUR PDRN ORIGIN

Our PDRN is sourced from highly purified salmon sperm DNA, chosen for its exceptional purity, structural similarity to human DNA, and ability to remain intact for optimal performance.

While many formulas rely on hydrolyzed or plant-derived DNA fragments—which mainly act as humectants—our use of intact, long-chain PDRN preserves the molecule’s natural integrity and enables superior performance when paired with our nano-emulsion delivery system.

PDRN VS. EXOSOME: WHEN TO USE EACH

Both ampoules deliver rejuvenation benefits, but they address different skin needs and use different biological pathways. 

Rejuvenative PDRN-NE Ampoule offers repair and resilience benefits. It helps soothe and strengthen the skin while reinforcing the moisture barrier, offering visible improvements in elasticity, comfort, and smoothness. Its richer emulsion texture makes it ideal for dry, mature, depleted, or fatigued skin in need of restoration, resilience, and renewed firmness.

 Regenerative 10B-EXO EGF Ampoule provides broad anti-aging benefits—helping visibly improve texture, elasticity, and tone while calming redness and supporting recovery. Its light, fast-absorbing texture makes it an excellent choice for combination, stressed, sensitive, or post-treatment skin.