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Retinal Infusion MLV5 Serum

Next-Generation
RETINOID Treatment

Multi-Lamellar Liposome
0.05% Pure Retinal

1% Bakuchiol ("PHYTO-RETINOL")

Centella Asiatica Exosomes

Sodium Hyaluronate

Retinal Infusion MLV5 Serum is a next-generation retinoid treatment designed for clinically-tested efficacy with minimal irritation. This advanced serum features 0.05% pure Retinal (retinaldehyde) – a potent Vitamin A derivative – delivered through an innovative dual-layer encapsulation system, and 1% Bakuchiol – a plant-derived alternative to retinol (a “phyto-retinol”) without having any of the negatives associated with retinol. The formulation also includes Centella Asiatica (Cica) Exosomes to visibly soothe and support the skin barrier, and Sodium Hyaluronate to deeply hydrate and fortify the moisture barrier. It visibly targets multiple signs of aging (wrinkles, uneven tone, and rough texture), while maintaining skin’s hydration and comfort. Clinically tested for visible improvements in skin quality, it offers a sophisticated yet gentle skin renewal experience.

The serum’s name, MLV5, refers to the Multi-Lamellar Vesicle (MLV) Technology encapsulating 0.05% pure Retinal. A 5% concentration of multi-lamellar liposomes is used to optimize skin absorption of the active. This advanced delivery system ensures that the powerful retinoid is stabilized, protected from degradation, and effectively delivered into the skin. As a result, users can achieve accelerated results with significantly reduced risk of irritation. The outcome is a highly effective retinoid treatment that balances clinical potency with minimal sensitization, making it appropriate for a wide range of skin types.

Clinically tested visible benefits in just 2 weeks (based on in-vivo clinical tests on 21 subjects over 2 weeks):
+ Visibly refined pores
+ Reduced the appearance of fine lines and wrinkles, including crow’s feet
+ Visibly improved skin texture
+ Reduced the look of pigmentation (melasma, dark spots, and freckles)
+ Improved skin hydration

Cruelty free. Leaping Bunny certified. None of our products, including the ingredients, are tested on animals.

Directions: Apply a pea-sized amount to clean, dry face and neck at night, avoiding the eye area and direct contact with eyes. Start with one application per week, then gradually increase to 2–3 times weekly, ensuring at least one day between applications, based on your skin’s tolerance. Once the serum absorbs, apply a moisturizer to help minimize dryness or irritation. If mild redness occurs, reduce frequency of use until skin adjusts. As Retinal can increase sun sensitivity, use a broad-spectrum sunscreen during the day. Do not combine with other retinol or retinoid products. Patch testing prior to use is advised.

Caution: Do not use on damaged or irritated skin. Do not use in case of allergy to any of the ingredients. For external use only. Discontinue use if signs of irritation or rash appear and consult a doctor. Avoid contact with eyes. In case of eye contact, rinse immediately with water. Avoid use during pregnancy or breastfeeding. Store in a cool and dry place, away from direct sunlight and heat. Keep out of the reach of children.

Retinal Dual-Layer Encapsulation

At the core of this technology, retinaldehyde is entrapped in an inner niosome vesicle along with a mineral layered double hydroxide nanostructure. This inner “niosomal” encapsulation stabilizes the highly reactive retinal molecule by shielding it from light and oxygen, preventing premature oxidation. Surrounding this core is an outer multi-lamellar liposome shell – concentric layers of lipid membranes composed of skin-mimicking lipids (including hydrogenated lecithin, cholesterol, macadamia seed oil, and caprylic/capric triglycerides). This outer liposomal envelope protects the active payload during storage and application while also enhancing its delivery into the skin.

Biomimetic Delivery and Controlled Release

The multi-lamellar liposome closely imitates the skin’s natural lipid barrier, which allows the serum to fuse more readily with the skin and deliver actives deeper into the skin. Upon application, the dual-layer capsule gradually releases retinal into the skin in a controlled manner. This means the 0.1% retinal is delivered over time rather than all at once, boosting efficacy while minimizing irritation.

An in-vitro skin permeability study demonstrated that a retinal formulation utilizing this advanced system delivers retinal into the skin nearly twice as effectively as a conventional retinal formulation that lacks such a delivery mechanism.

1% Bakuchiol, A PHYTO-RETINOL

Bakuchiol, a natural compound derived from the Babchi plant, reinforces the retinoid results through similar biological pathways: it boosts collagen synthesis, helps prevent the breakdown of extracellular matrix proteins, and improves cellular turnover. In clinical trials, Bakuchiol has demonstrated comparable improvements to retinol in reducing the appearance of fine lines, wrinkles, and hyperpigmentation, without the typical irritation associated with retinol use. By combining Bakuchiol with retinaldehyde, the formulation amplifies anti-aging efficacy – addressing the appearance of wrinkles, firmness, and tone – while remaining gentle on the skin.

Centella Asiatica Exosomes

Advanced nano-sized vesicles are extracted from the Centella Asiatica plant (famously known as “Cica”). In this formulation, Centella Asiatica exosomes help offset any potential irritation from the retinoid. They provide deep hydration and help reinforce the skin’s moisture barrier, which is crucial when using a strong active like retinal. By strengthening the barrier and delivering soothing compounds into the skin, these exosomes visibly reduce redness and discomfort and promote a healthier, resilient complexion during the retinal treatment process.

Sodium Hyaluronate

With its ability to hold up to 1,000 times its weight in water, sodium hyaluronate penetrates into the superficial layers of the skin to attract and retain moisture. This ensures that the skin stays visibly plump and well-hydrated, counteracting the drying effects that potent retinoids can sometimes cause. By maintaining optimal hydration levels, sodium hyaluronate helps keep the skin comfortable and supple, and it further supports the skin barrier function.